Structural biologists at the Friedrich Miescher Institute for Biomedical Research have resolved the 3D structure of a protein machine that plays an important part in the maintenance of genomic stability. They have revealed how one unit of the machine, RMI, modulates the workings of an enzyme, topoisomerase IIIα (TopIIIα), thus allowing double Holliday junctions – key intermediates in DNA repair – to be disentangled. Their results have been published in Nature Structural & Molecular Biology.
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